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201 SVHCs on the REACH Candidate List

Four new REACH substances were added to the European Union (EU) REACH Candidate List of SVHCs on July 16th, 2019.

New 201 SVHC on the REACH Candidate List - Applications and Health Concerns

Below is a table with details concerning the four substances added to the REACH Candidate List of SVHCs candidate list

Substance Name


Where used

Health Concerns

2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, its salts, and its acyl halides (covering any of their isomers and combinations thereof); HFPO-DA


Used in the manufacturing process of fluoropolymer resins

Manufacturers apply these resins in many products, such as wire cables or PTFE (Teflon) coating.

  • Corrosive, causes serious eye damage and severe skin burns
  • May cause respiratory irritation
  • Oral toxicity (harmful if swallowed)
  • Damages liver

2-methoxyethyl acetate


  • Historically used as a process solvent for:
  • Gums
  • Resins
  • Waxes
  • Oils
  • Manufacture of semiconductors
  • Textile
  • Painting
  • Photographic films
  • etc. 

  • Also used as an intermediate in industrial applications
  • Reprotoxic (damages fertility and unborn child)
  • Irritates skin
  • Oral toxicity (harmful if swallowed)

Tris(4-nonylphenyl, branched and linear) phosphite (TNPP) with ≥ 0.1% w/w of 4-nonylphenol, branched and linear (4-NP)


Employed as an antioxidant in:

  • Polymers
  • Electronics
  • Paintings
  • Adhesives
  • Toys
  • Papers
  • Cardboards 
  • Irritant, may cause an allergic reaction to the skin
  • Causes acute and long-term damage to aquatic environments
  • Disrupts endocrine



  • Plasticizer
  • Industrial intermediate in some resins and plastics
  • Used in insecticides and industrial perfumes
  • Corrosive, causes serious eye damage and severe skin burns
  • Reprotoxic (affects reproduction, may damage fertility)
  • Causes long-term damage to aquatic environments
  • Causes difficulty breathing if inhaled
  • Emits toxic fumes when heated
  • May impair liver and nervous system after chronic exposure
  • Disrupts endocrine

We have updated our Enviropass Product Environmental Compliance EPEC Form to reflect the current REACH candidate list of SVHCs and Annex XVII list.

REACH Candidate List - SVHC Hazard Categories

REACH Candidate List
Hazardous Chemicals - Reprotoxic

Article 57 of the REACH regulation denotes different hazard categories for substances in the SVHC candidate list. Specifically, the European Chemicals Agency (ECHA) may include substances that are:

  • Carcinogenic
  • Mutagenic
  • Toxic for reproduction
  • Persistent, bioaccumulative, and toxic (PBT)
  • Very persistent and very bioaccumulative (vPvB)
  • Having endocrine-disrupting properties

What is the Endocrine System?

Given that the ECHA added two of the four chemicals new to REACH candidate list of SVHCs due to their endocrine-disrupting properties, it is wise to clarify this term.

The endocrine system is composed of the body’s organs and glands that produce and release hormones. These hormones are essential to the body’s proper functioning, as they control operations such as:

  • Metabolism
  • Heart rate
  • Growth and development
  • Appetite
  • Body temperature
  • Blood pressure
  • Sleep/Wake cycle
  • Reproduction
SVHC endocrine disruptes

What Are Endocrine Disrupting Properties?

Endocrine disruptors are chemicals that interfere which the body’s production and secretion of hormones. They can be very detrimental to an organism’s health since proper functioning of the endocrine system is critical for a well-working body.

Symptoms of endocrine disruption include:

  • Inhibited immune system
  • Impaired nervous system
  • Increased risk of cancer
  • Early puberty
  • Weight loss or gain
  • Developmental defects
  • Loss of fertility
Endocrine Disrupting Properties

Finally, endocrine disruptors may have long-lasting effects on the environment and are harmful to humans and wildlife.

Visit our article on other hazardous chemicals in your products.

Do you want to know more about REACH product environmental compliance? Should you have any questions, contact Enviropass.